Vytorin (ezetimibe/simvastatin) Coupons, Discounts & Cost
Vytorin (ezetimibe/simvastatin) is used to lower cholesterol in the blood. One way to save money on the Vytorin retail cost regardless of income and insurance status is to use Vytorin coupons or discount cards from RXCoupons. Use this Ezetimibe/Simvastatin coupon at this online pharmacy and receive up to 75% off the sale price.
Indications for use of Vytorin
Vytorin (ezetimibe/simvastatin) is used to lower cholesterol in the blood. Vytorin helps reduce the amount of cholesterol produced by the liver, as well as reduce the risk of atherosclerosis.
Simvastatin inhibits the synthesis of cholesterol in the liver. As a result, the concentration of cholesterol and lipoproteins in the blood will be lower (cholesterol - by 30-45%, low density lipoproteins - by 40-60%, triglycerides - by 15-33%, apolipoprotein B100 by 35-50%). In addition, simvastatin increases the concentration of high density lipoproteins and apolipoprotein A. Simvastatin minimizes the risk of vascular complications of coronary heart disease, reduces the risk of myocardial infarction.
Ezetimibe blocks the absorption of cholesterol in the small intestine. It reduces the absorption of cholesterol in the intestine by 54% within 2 weeks. This agent does not affect the absorption of triglycerides, fatty acids, progesterone, ethinyl estradiol, vitamins A and D.
Vytorin is used to treat primary hypercholesterolemia in patients with an increased risk of coronary atherosclerosis. It is also used for the prevention of stroke and myocardial infarction (in order to avoid revascularization procedures).
When Vytorin is contraindicated
Care should be taken in case of hepatitis (active phase), individual intolerance. Do not use in children under 5 years of age.
Use carefully in patients with severe renal failure, liver disease, alcohol abuse. Use with caution in children under 12 years of age.
Simvastatin is contraindicated in pregnancy and lactation.
How to use Vytorin
Children:
5-10 years of age: 5 mg at night. If necessary, the dose can be increased after 4 weeks to 20 mg (maximum dose).
10-18 years of age: 10 mg at night. If necessary, the dose can be increased after 4 weeks to 40 mg (maximum dose).
Adults:
The drug should be taken once a day. The initial dose is 10 mg per day. You will feel the effect within two weeks after you’ve started using Vytorin. The dose can be adjusted depending on the effectiveness of therapy.
Patients with primary hypercholesterolemia should take this drug daily at a dose of 10/40 mg (10 mg of ezetimibe + 40 mg of simvastatin), or 10/80 mg (10 mg of ezetimibe + 80 mg of simvastatin).
The highest single dose: 80 mg.
The highest daily dose: 80 mg.
Elderly patients and patients with mild liver failure may not change the dose.
Vytorin is not recommended for patients with moderate or severe liver failure.
Patients with moderate renal failure may not change the dose. As for patients with severe renal failure, the drug should be taken in a dose of more than 10/10mg per day.
Possible side effects
CNS: headache, dizziness, unpleasant dreams, peripheral neuropathy, migraine.
Cardiovascular system: palpitation, orthostatic hypotension, arrhythmia.
Hematopoiesis: anemia, thrombocytopenia.
Respiratory system: exacerbation of bronchial asthma.
Muscular system: myopathy.
Digestive system: nausea, dysphagia, stomatitis, hepatitis, rectal bleeding, rectal tenesmus.
Genitourinary system: discomfort associated with urination, impotence.
Other systems: tinnitus, amblyopia, allergic reactions.
Vytorin interaction with other drugs
Grapefruit juice increases the concentration of simvastatin (high risk of side effects - myopathy).
It is not recommended to take alcohol during treatment.
Antifungal agents, erythromycin, cyclosporine can increase the concentration of simvastatin by 40%. Digoxin can increase the concentration of simvastatin by 20%.
Vytorin special instructions
Alcohol has harmful interactions with Vytorin. People with chronic alcoholism should avoid taking this drug.